trans-4-Hydroxytamoxifen
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $750 | Check With Us |
| 250mg | $1450 | Check With Us |
| 500mg | $2175 | Check With Us |
: Cat #: V16693 CAS #: 68047-06-3 Purity ≥ 99%
Description: trans-4-Hydroxytamoxifen is an active metabolite of tamoxifen which is an ER antagonist and selective estrogen receptor modulator (SERM).
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| Molecular Weight (MW) | 387.52 |
|---|---|
| Molecular Formula | C26H29NO2 |
| CAS No. | 68047-06-3 |
| Synonyms | ICI 79280; trans-4-Hydroxytamoxifen |
| Protocol | In Vitro | 4-Hydroxytamoxifen (Monohydroxytamoxifen) is a selective estrogen receptor antagonist, [3H]oestradiol IC that binds to estrogen receptors50 is 3.3 nM. 4-Hydroxytamoxifen (10,100 nM) inhibits [3H]oestradiol binds to human 8S estrogen receptors |
|---|---|---|
| In Vivo | 4-Hydroxytamoxifen (0.2, 1, and 5 micrograms/day orally) caused a decrease in wet weight dose in immature rats |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5805 mL | 12.9026 mL | 25.8051 mL | 51.6102 mL |
| 5mM | 0.5161 mL | 2.5805 mL | 5.1610 mL | 10.3220 mL |
| 10mM | 0.2581 mL | 1.2903 mL | 2.5805 mL | 5.1610 mL |
| 20mM | 0.1290 mL | 0.6451 mL | 1.2903 mL | 2.5805 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.