Finerenone (BAY94-8862)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$800	Check With Us
5g	$2160	Check With Us
10g	$3240	Check With Us

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Cat #: V15818 CAS #: 1050477-31-0 Purity ≥ 98%

Description: Finerenone (formerly known as BAY94-8862; BAY-948862; Kerendia) is a potent, selective, and orally bioavailable non-steroidal anti-mineralocorticoid or mineralocorticoid receptor (MR) antagonist (IC50 = 18 nM) that was approved in July 2021 by the US FDA to reduce the risk of kidney and heart complications in chronic kidney disease associated with type 2 diabetes.

References: Bärfacker L, et al. Discovery of BAY 94-8862: a nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseases. ChemMedChem. 2012;7(8):1385-1403.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	378.42
Molecular Formula	C21H22N4O3
CAS No.	1050477-31-0
SMILES Code	O=C(C1=C(C)NC2=C(C(OCC)=NC=C2C)[C@@H]1C3=CC=C(C#N)C=C3OC)N

Protocol	In Vivo	Finerenone (BAY 94-8862) lowers albuminuria by >40% and significantly reduces systolic blood pressure (SBP) in Munich Wistar Frömter (MWF) rat
	Animal model	Twelve-week-old MWF rat
	Dosages	10 mg/kg
	Administration	P.o.; daily for 4 weeks

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.6426 mL	13.2128 mL	26.4257 mL	52.8513 mL
5mM	0.5285 mL	2.6426 mL	5.2851 mL	10.5703 mL
10mM	0.2643 mL	1.3213 mL	2.6426 mL	5.2851 mL
20mM	0.1321 mL	0.6606 mL	1.3213 mL	2.6426 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.