GW9508
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $450 | Check With Us |
| 500mg | $750 | Check With Us |
| 1g | $1125 | Check With Us |
: Cat #: V1805 CAS #: 885101-89-3 Purity ≥ 98%
Description: GW9508 is a novel, potent and selective agonist for FFA1 (fatty acid receptor GPR40) with pEC50 of 7.32, and is 100-fold selective against GPR120, it stimulates insulin secretion in a glucose-sensitive manner.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 347.41 |
|---|---|
| Molecular Formula | C22H21NO3 |
| CAS No. | 885101-89-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 69 mg/mL (198.6 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 69 mg/mL (198.6 mM) | |
| Synonyms | GW9508; GW-9508; GW 9508. |
| Protocol | In Vitro | GW9508 inhibits CCL17 and CCL5 expression in pertussis toxin-sensitive cells. The inhibition of GW9508 can be eliminated by depleting GPR40 using RNA interference. GW9508 further inhibits the expression of IL-11, IL-24, and IL-33 induced by TNF-α and IFN-γ in HaCaT cells. GW9508 also inhibits the production of CCL5 and CXCL10 by normal human epidermal keratinocytes |
|---|---|---|
| In Vivo | In repeated hapten application models (BALB/c and C57BL/6 mice), topical administration of 200 (μM) of GW9508 to the skin inhibits ear swelling and inhibits contact hypersensitivity reactions by downregulating CCL5 and CXCL10, respectively |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8784 mL | 14.3922 mL | 28.7844 mL | 57.5689 mL |
| 5mM | 0.5757 mL | 2.8784 mL | 5.7569 mL | 11.5138 mL |
| 10mM | 0.2878 mL | 1.4392 mL | 2.8784 mL | 5.7569 mL |
| 20mM | 0.1439 mL | 0.7196 mL | 1.4392 mL | 2.8784 mL |
The molarity calculator equation
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
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mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.