Exemestane (FCE 24304; EXE)

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
1g	$250	Check With Us
10g	$1150	Check With Us
20g	$1725	Check With Us

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Cat #: V1800 CAS #: 107868-30-4 Purity ≥ 98%

Description: Exemestane (formerly also known as FCE24304, PNU155971; FCE 24304; EXE), a drug used in ER-positive breast cancer, is a synthetic and potent aromatase inhibitor, which inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.

References: Goss, P.E., et al., Effects of the steroidal aromatase inhibitor exemestane and the nonsteroidal aromatase inhibitor letrozole on bone and lipid metabolism in ovariectomized rats. Clin Cancer Res, 2004. 10(17): p. 5717-23.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	296.4
Molecular Formula	C20H24O2
CAS No.	107868-30-4
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 54 mg/mL (182.2 mM)r
	Water: <1 mg/mLr
	Ethanol: 15 mg/mL (50.6 mM)
Synonyms	FCE24304, PNU155971; PNU155971; PNU-155971; PNU 155971; FCE24304; FCE-24304; FCE 24304; Exemestane; US trade name: Aromasin.

Protocol	In Vivo	Exemestane (EXE; 20-100 mg/kg; intramuscular injection; once weekly; for 16 weeks) treatment significantly increases the lumbar vertebral and femoral BMD, bending strength of the femur, compressive strength of the fifth lumbar vertebra, and trabecular bone volume. Exemestane significantly reduces an ovariectomy-induced increase in serum pyridinoline and serum osteocalcin. Exemestane causes significant reductions of serum cholesterol and low-density lipoprotein cholesterol
	Animal model	Female Sprague Dawley rats (10-month-old) bearing ovariectomy
	Dosages	20 mg/kg, 50 mg/kg, or 100 mg/kg
	Administration	Intramuscular injection; once weekly; for 16 weeks

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.3738 mL	16.8691 mL	33.7382 mL	67.4764 mL
5mM	0.6748 mL	3.3738 mL	6.7476 mL	13.4953 mL
10mM	0.3374 mL	1.6869 mL	3.3738 mL	6.7476 mL
20mM	0.1687 mL	0.8435 mL	1.6869 mL	3.3738 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.