Anastrozole (ZD1033)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $390 | In Stock |
| 2g | $590 | In Stock |
| 5g | $900 | In Stock |
: Cat #: V1799 CAS #: 120511-73-1 Purity ≥ 98%
Description: Anastrozole (formerly known as ZD-1033) is a potent, third-generation nonsteroidal and selective inhibitor of aromatase with an IC50 of 15 nM for inhibiting human placental aromatase.
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| Molecular Weight (MW) | 293.37 |
|---|---|
| Molecular Formula | C17H19N5 |
| CAS No. | 120511-73-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 59 mg/mL (201.1 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 59 mg/mL (201.1 mM) | |
| Synonyms | ZD-1033; ZD1033; ZD 1033; CCRIS 9352; HSDB 7462; ICI D1033; Anastrozole (ANAS); Trade name: Arimidex. Chemical Name: 2,2'-(5-((1H-1,2,4-triazol-1-yl)methyl)-1,3-phenylene)bis(2-methylpropanenitrile) Exact Mass: 293.16405 |
| Protocol | In Vitro | Anastrozole is a comparatively simple, achiral benzyltriazole derivative, that inhibits human placental aromatase with an IC50 of 15 nM. In the same assay it is 200 times as potent as aminoglutethimide (AG), twice as potent as 4-OHA and one third as potent as Fadrozole |
|---|---|---|
| In Vivo | Groups of eight immature (22-day-old) female rats are given androstenedione (AD) (30 mg/kg) in arachis oil s.c. daily for 3 days with or without various doses of Anastrozole p.o. on day 4 the uteri are dissected, blotted and weighed. An oral dose of 0.1 mg/kg of Anastrozole given on day 2 or day 3 of the cycle completely blocked ovulation. At the same daily dosage (0.1 mg/kg), Anastrozole completely extinguished the uterotrophic activity of exogenous AD in immature rats. In male pigtailed monkeys, twice-daily oral treatment with 0.1 mg/kg and above of Anastrozole reduced circulating oestradiol concentrations by 50-60% |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.4087 mL | 17.0433 mL | 34.0866 mL | 68.1733 mL |
| 5mM | 0.6817 mL | 3.4087 mL | 6.8173 mL | 13.6347 mL |
| 10mM | 0.3409 mL | 1.7043 mL | 3.4087 mL | 6.8173 mL |
| 20mM | 0.1704 mL | 0.8522 mL | 1.7043 mL | 3.4087 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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V1
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.