Imidapril HCl (TA-6366)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$505	Check With Us
500mg	$845	Check With Us
1g	$1265	Check With Us

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Cat #: V1789 CAS #: 89396-94-1 Purity ≥ 98%

Description: Imidapril HCl (TA-6366; TA-6366; Tanatril), the hydrochloride salt of imidapril, is a potent angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, approved in 1993 for use as an antihypertensive drug and for the treatment of chronic heart failure.

References: Robinson DM, et al. Imidapril: a review of its use in essential hypertension, Type 1 diabetic nephropathy and chronic heart failure. Drugs. 2007;67(9):1359-78.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	441.91
Molecular Formula	C20H27N3O6.HCl
CAS No.	89396-94-1
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 88 mg/mL (199.1 mM)r
	Water: 54 mg/mL (122.19 mM)r
	Ethanol: 29 mg/mL (65.6 mM)
Synonyms	TA-6366; TA 6366; TA6366;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2629 mL	11.3145 mL	22.6290 mL	45.2581 mL
5mM	0.4526 mL	2.2629 mL	4.5258 mL	9.0516 mL
10mM	0.2263 mL	1.1315 mL	2.2629 mL	4.5258 mL
20mM	0.1131 mL	0.5657 mL	1.1315 mL	2.2629 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.