Azilsartan (TAK-536)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $445 | Check With Us |
| 10g | $700 | Check With Us |
| 20g | $1050 | Check With Us |
: Cat #: V1790 CAS #: 147403-03-0 Purity ≥ 98%
Description: Azilsartan (TAK-536; TAK536; Edarbi; Ipreziv) is a potent and orally bioavailable angiotensin II type 1 (AT1) receptor antagonist with antihypertensive effects.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 456.45 |
|---|---|
| Molecular Formula | C25H20N4O5 |
| CAS No. | 147403-03-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 91 mg/mL (199.3 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | 30% PEG400+0.5% Tween80+5% Propylene glycol: 30 mg/mL |
| Synonyms | TAK-536; TAK-536; TAK-536; Edarbi |
| Protocol | In Vivo | Azilsartan (0-3 mg/kg, Oral gavage, once daily for 5 days) decreases SBP (systolic blood pressure) in obese Koletsky rats at 2 mg/kg |
|---|---|---|
| Animal model | Male Wistar-Kyoto (WKY) rats, obese Koletsky rats (n=6 per group) | |
| Dosages | 0, 1, 2 and 3 mg/kg | |
| Administration | Oral gavage, once daily (9:00-10:00 hours) for 5 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1908 mL | 10.9541 mL | 21.9082 mL | 43.8164 mL |
| 5mM | 0.4382 mL | 2.1908 mL | 4.3816 mL | 8.7633 mL |
| 10mM | 0.2191 mL | 1.0954 mL | 2.1908 mL | 4.3816 mL |
| 20mM | 0.1095 mL | 0.5477 mL | 1.0954 mL | 2.1908 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.