Aliskiren Hemifumarate (CGP 60536)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $450 | Check With Us |
| 1g | $650 | Check With Us |
| 5g | $1755 | Check With Us |
: Cat #: V1771 CAS #: 173334-58-2 Purity ≥ 98%
Description: Aliskiren hemifumarate (CGP-60536; CGP60536; Rasilez; SPP100; SPP-100; Tekturna), the hemifumarate salt form of Aliskiren, is a potent and direct renin inhibitor with antihypertensive activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 609.83 |
|---|---|
| Molecular Formula | C30H53N3O6.1/2C4H4O4 |
| CAS No. | 173334-58-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (164.0 mM)r |
| Water: 100 mg/mL (164.0 mM)r | |
| Ethanol: 100 mg/mL (164.0 mM) | |
| Synonyms | CGP060536B; SPP-100; CGP 060536B; SPP 100; CGP-060536B; Rasilez; SPP100; Tekturna |
| Protocol | In Vivo | Aliskiren hemifumarate (3 mg/kg, 10 mg/kg; p.o.; daily; 0-12 d) inhibit renin and lower blood pressure without affecting heart rate in sodium-depleted marmosets |
|---|---|---|
| Animal model | Sodium-depleted marmosets | |
| Dosages | 3 mg/kg, 10 mg/kg | |
| Administration | Oral gavage; once daily; 12 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.6398 mL | 8.1990 mL | 16.3980 mL | 32.7960 mL |
| 5mM | 0.3280 mL | 1.6398 mL | 3.2796 mL | 6.5592 mL |
| 10mM | 0.1640 mL | 0.8199 mL | 1.6398 mL | 3.2796 mL |
| 20mM | 0.0820 mL | 0.4100 mL | 0.8199 mL | 1.6398 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.