Losartan Potassium (DuP 753)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
10g	$200	Check With Us
100g	$1050	Check With Us
200g	$1575	Check With Us

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Cat #: V1773 CAS #: 124750-99-8 Purity ≥ 98%

Description: Losartan Potassium (formerly DuP-753; MK-954; DuP753; MK954; Cozaar; Lorzaar; Losaprex), the potassium salt of losartan, is an oral, selective, and non-peptide angiotensin II receptor antagonist approved as an antihypertensive drug.

References: Choi, C.H., et al. Angiotensin II type I receptor and miR-155 in endometrial cancers: synergistic antiproliferative effects of anti-miR-155 and losartan on endometrial cancer cells. Gynecol Oncol, 2012. 126(1): p. 124-31.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	462.01
Molecular Formula	C22H23ClKN6O
CAS No.	124750-99-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 92 mg/mL (199.1 mM)r
	Water: 92 mg/mL (199.1 mM)r
	Ethanol: 92 mg/mL (199.1 mM)
Solubility In Vivo	Saline: 30 mg/mL
Synonyms	DuP 753; MK 954; DuP-753; MK-954; DuP753; MK954; Cozaar; Lorzaar; Losaprex; UNII-3ST302B24A; MK954;

Protocol	In Vitro	Losartan potassium (40 μM) influence ISC But block the ANGII pair ISCImpact [2]。 Losartan potassium significantly reduces Ang II-mediated cell proliferation in endometrial cancer cells. The combination of Losartan potassium and anti-miR-155 has significantly stronger antiproliferative effects than each drug alone

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.1645 mL	10.8223 mL	21.6446 mL	43.2891 mL
5mM	0.4329 mL	2.1645 mL	4.3289 mL	8.6578 mL
10mM	0.2164 mL	1.0822 mL	2.1645 mL	4.3289 mL
20mM	0.1082 mL	0.5411 mL	1.0822 mL	2.1645 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.