Irbesartan (SR-47436; BMS-186295)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $250 | Check With Us |
| 2g | $400 | Check With Us |
| 5g | $650 | Check With Us |
: Cat #: V1776 CAS #: 138402-11-6 Purity ≥ 98%
Description: Irbesartan (formerly known as SR47436; BMS186295; SR-47436; BMS-186295; Avapro, Aprovel, Karvea) is a highly potent and specific angiotensin II type 1 (AT II-1) receptor antagonist/ARB approved as an antihypertension drug.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 428.53 |
|---|---|
| Molecular Formula | C25H28N6O |
| CAS No. | 138402-11-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 4 mg/mL (9.3 mM)r |
| Water:<1 mg/mLr | |
| Ethanol: 3 mg/mL (7.0 mM) | |
| Solubility In Vivo | 30% PEG400+0.5% Tween80+5% Propylene glycol: 30 mg/mL |
| Synonyms | BMS-186295, SR-47436; BMS 186295, SR 47436; BMS186295, SR47436; Avapro, Aprovel, Karvea |
| Protocol | In Vitro | Irbesartan (0 μM, 20 μM, 40 μM and 60 μM) suppresses Th22 cells differentiation in vitro |
|---|---|---|
| In Vivo | Irbesartan hydrochloride (20 μM; for 3 h) can attenuate Th22 cells recruitment and IL-22 secretion, which might be through inhibiting chemotaxis in hypertensive renal injury mice | |
| Animal model | C57BL/6 mice | |
| Dosages | 50 mg/kg | |
| Administration | oral gavage; 50 mg/kg/d; once daily |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3336 mL | 11.6678 mL | 23.3356 mL | 46.6712 mL |
| 5mM | 0.4667 mL | 2.3336 mL | 4.6671 mL | 9.3342 mL |
| 10mM | 0.2334 mL | 1.1668 mL | 2.3336 mL | 4.6671 mL |
| 20mM | 0.1167 mL | 0.5834 mL | 1.1668 mL | 2.3336 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.