UT-34
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $700 | Check With Us |
| 100mg | $1150 | Check With Us |
| 200mg | $1725 | Check With Us |
: Cat #: V38848 CAS #: 2168525-92-4 Purity ≥ 99%
Description: UT-34 (UT34) is a novel, selective, and orally bioavailable pan-androgen receptor (AR) antagonist and also a selective androgen receptor degrader (SARD) with anti-prostate cancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 356.27 |
|---|---|
| Molecular Formula | C₁₅H₁₂F₄N₄O₂ |
| CAS No. | 2168525-92-4 |
| SMILES Code | O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)[C@@](C)(O)CN2N=CC(F)=C2 |
| Synonyms | UT34 |
| Protocol | In Vitro | UT-34 (3-10 µM; 24 hours; LNCaP cells) treatment inhibits the expression of PSA and FKBP5 and growth of LNCaP cells starting from 100 nM with maximum effect observed at 10 μM |
|---|---|---|
| In Vivo | UT-34 (20-40 mg/kg; oral administration; daily; for 14 days; NSG mice) at 20 and 40 mg/kg reduces the seminal vesicle weight by 10%-20% and 50%-60 %, respectively | |
| Animal model | Non obese diabetic/severe combined immunodeficiency Gamma (NSG) mice injected with MR49F cells | |
| Dosages | 20 mg/kg or 40 mg/kg | |
| Administration | Oral administration; daily; for 14 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8069 mL | 14.0343 mL | 28.0686 mL | 56.1372 mL |
| 5mM | 0.5614 mL | 2.8069 mL | 5.6137 mL | 11.2274 mL |
| 10mM | 0.2807 mL | 1.4034 mL | 2.8069 mL | 5.6137 mL |
| 20mM | 0.1403 mL | 0.7017 mL | 1.4034 mL | 2.8069 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.