Bicalutamide (Casodex; ICI-176334)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
10g	$345	Check With Us
20g	$520	Check With Us
50g	$810	Check With Us

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Cat #: V1758 CAS #: 90357-06-5 Purity ≥ 98%

Description: Bicalutamide (formerly known as ICI-176334; CDX; trade names: Casodex in the USA and Cosudex in other countries), a marketed drug for treating PC (prostate cancer), is a potent, synthetic, nonsteroidal androgen receptor (AR) antagonist with potential anticancer activity.

References: Nicola J. Clegg,1 John Wongvipat,1,2 Jim Joseph, ARN-509: a novel anti-androgen for prostate cancer treatment. Cancer Res. 2012 March 15; 72(6): 1494-1503.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	430.37
Molecular Formula	C18H14F4N2O4S
CAS No.	90357-06-5
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 86 mg/mL (199.8 mM)r
	Water: <1 mg/mLr
	Ethanol: 5 mg/mL (11.6 mM)
Solubility In Vivo	Chemical Name: N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide InChi Key: LKJPYSCBVHEWIU-UHFFFAOYSA-N InChi Code: InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25) SMILES Code: O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)C(C)(O)CS(=O)(C2=CC=C(F)C=C2)=O
Synonyms	ICI-176334; ICI 176334; ICI176334; CDX. US trade name: Casodex; Cosudex.

Protocol	In Vitro	In whole-cell binding assays (LNCaP/AR (cs) cells), Bicalutamide competes with androgens to bind AR,IC50 is 160 nM
	In Vivo	Bicalutamide (10 mg/kg； ig； Every day; for 28 days) showed antitumor activity in a mouse model of prostate cancer
	Animal model	Castrate male mice, bearing LNCaP/AR(cs) xenograft tumors
	Dosages	10 mg/kg
	Administration	Oral gavage, daily, for 28 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3236 mL	11.6179 mL	23.2358 mL	46.4716 mL
5mM	0.4647 mL	2.3236 mL	4.6472 mL	9.2943 mL
10mM	0.2324 mL	1.1618 mL	2.3236 mL	4.6472 mL
20mM	0.1162 mL	0.5809 mL	1.1618 mL	2.3236 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.