N-desmethyl Enzalutamide (N-desmethyl MDV 3100)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $635 | Check With Us |
| 250mg | $1075 | Check With Us |
| 500mg | $1610 | Check With Us |
: Cat #: V33450 CAS #: 1242137-16-1 Purity ≥ 98%
Description: N-desmethyl Enzalutamide (N-desmethyl MDV 3100) is an active metabolite of Enzalutamide which is is a novel, potent, orally bioavailable, organic, non-steroidal small molecule, second-generation androgen-receptor (AR) antagonist.
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| Molecular Weight (MW) | 450.41 |
|---|---|
| Molecular Formula | C₂₀H₁₄F₄N₄O₂S |
| CAS No. | 1242137-16-1 |
| Synonyms | N-desmethyl MDV 3100; N-desmethyl MDV-3100; N-desmethyl MDV3100 |
| Protocol | In Vivo | N-desmethyl Enzalutamide is an active metabolite that is thought to contribute to the clinical effect of enzalutamide, as it shows major and secondary pharmacodynamics similar to enzalutamide and circulates at plasma concentrations approximately the same as enzalutamide. Carboxylic acid metabolites are pharmacologically inactive and circulating plasma concentrations are approximately 25% lower than enzalutamide |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2202 mL | 11.1010 mL | 22.2020 mL | 44.4040 mL |
| 5mM | 0.4440 mL | 2.2202 mL | 4.4404 mL | 8.8808 mL |
| 10mM | 0.2220 mL | 1.1101 mL | 2.2202 mL | 4.4404 mL |
| 20mM | 0.1110 mL | 0.5550 mL | 1.1101 mL | 2.2202 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.