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Bavdegalutamide (ARV-110)

This product is for research use only, not for human use. We do not sell to patients.

Bavdegalutamide (ARV-110)
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Size Price Stock
100mg$750Check With Us
250mg$1250Check With Us
500mg$1875Check With Us
email: [email protected]        [email protected]

Cat #: V41443 CAS #: 2222112-77-6 Purity ≥ 99%

Description: Bavdegalutamide (ARV110; ARV-110) is an orally bioavailable PROTAC-based Androgen Receptor (AR) degrader with potential anticancer activity.

References: Taavi K Neklesa,et al. ARV-110: an oral androgen receptor PROTAC degrader for prostate cancer. GU ASCO 2019

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Molecular Weight (MW)812.3004
Molecular FormulaC41H43ClFN9O6
CAS No.2222112-77-6
ProtocolIn VitroBavdegalutamide (10-1000 nM) suppresses the expression of the AR-target gene PSA, inhibits AR-dependent cell proliferation, and induces apoptosis at low nanomolar concentrations.
In VivoBavdegalutamide (oral gavage; 1 mg/kg; QD) exhibits a greater than 90% AR degradation in vivo. In LNCaP, VCaP and prostate cancer patient derived xenograft (PDX) models, Bavdegalutamide also exhibits significant inhibition of tumor growth and AR signaling.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.2311 mL6.1554 mL12.3107 mL24.6214 mL
5mM0.2462 mL1.2311 mL2.4621 mL4.9243 mL
10mM0.1231 mL0.6155 mL1.2311 mL2.4621 mL
20mM0.0616 mL0.3078 mL0.6155 mL1.2311 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.