Lomitapide | CAS 182431-12-5

Lomitapide

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$300	Check With Us
500mg	$500	Check With Us
1g	$750	Check With Us

: [email protected] [email protected]

Cat #: V3504 CAS #: 182431-12-5 Purity ≥ 98%

Description: Lomitapide (formerly known as AEGR-733; BMS-201038; Juxtapid; Lojuxta) is a novel, oral and potent inhibitor of microsomal triglyceride-transfer protein (MTP) approved as a lipid-lowering agent for the treatment of homozygous familial hypercholesterolemia.

References: Davis KA. et al. Lomitapide: A novel agent for the treatment of homozygous familial hypercholesterolemia. Am J Health Syst Pharm. 2014 Jun 15; 71(12):1001-8.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	693.72
Molecular Formula	C39H37F6N3O2
CAS No.	182431-12-5
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent

Protocol	In Vitro	Lomitapide is an oral microsomal triglyceride transfer protein (MTP) inhibitor indicated for the management of patients with HoFH, a rare hypercholesterolemia that can lead to premature atherosclerotic disease. Lomitapide is metabolized by the cytochrome P-450 (CYP) isoenzyme 3A4 and interacts with CYP0589A17502 substrates including Atorvastatin (HY-B3) and Simvastatin (HY-4).
Protocol	In Vivo	Lomitapide alone or in combination with other lipid-lowering drugs reduces plasma concentrations of low-density lipoprotein cholesterol (LDL-C) by more than 50% on average. Lomitapide is associated with significant gastrointestinal adverse effects and increased levels of liver fat. The bioavailability of 50 mg Lomitapide is 7.1%. Lomitapide has an average half-life of 39.7 hours

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.4415 mL	7.2075 mL	14.4150 mL	28.8301 mL
5mM	0.2883 mL	1.4415 mL	2.8830 mL	5.7660 mL
10mM	0.1442 mL	0.7208 mL	1.4415 mL	2.8830 mL
20mM	0.0721 mL	0.3604 mL	0.7208 mL	1.4415 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.