Benzamil hydrochloride

This product is for research use only, not for human use. We do not sell to patients.

Benzamil hydrochloride
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$600Check With Us
500mg$990Check With Us
1g$1485Check With Us

Cat #: V32490 CAS #: 161804-20-2 Purity ≥ 99%

Description: Benzamil HCl, the hydrochloride salt of Benzamil which is an amiloride analog, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM) with the potential to treat cystic fibrosis.

References: Castañeda MS, et al. Benzamil inhibits neuronal and heterologously expressed small conductance Ca2+-activated K+channels. Neuropharmacology. 2019 Nov 1;158:107738.

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Promise
Molecular Weight (MW)356.21
Molecular FormulaC₁₃H₁₅Cl₂N₇O
CAS No.161804-20-2
SynonymsBenzylamiloride hydrochloride
ProtocolIn VitroBenzamil hydrochloride (Benzylamiloride hydrochloride) inhibits neuronal and heterologously expressed small conductance Ca2+-activated K2+ channels
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.8073 mL14.0367 mL28.0733 mL56.1467 mL
5mM0.5615 mL2.8073 mL5.6147 mL11.2293 mL
10mM0.2807 mL1.4037 mL2.8073 mL5.6147 mL
20mM0.1404 mL0.7018 mL1.4037 mL2.8073 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.