Lesinurad sodium

This product is for research use only, not for human use. We do not sell to patients.

Lesinurad sodium
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Size Price Stock
250mg$450Check With Us
500mg$750Check With Us
1g$1125Check With Us

Cat #: V3306 CAS #: 1151516-14-1 Purity ≥ 98%

Description: Lesinurad sodium (formerly known as RDEA594; RDEA-594; trade name Zurampic), the sodium salt of lesinurad, is a selective inhibitor of URAT1 (urate transporter 1) and OAT (organic anion transporter) approved in 2015 for treating high blood uric acid levels associated with gout.

References: L.Yeh, et al. RDEA594, a potential uric acid lowering agent througn inhibition of uric acid reuptake ,shows better pharmacokinetics rhan its prodrug RDEA806. 2008 ACR/ARHP Annual Scientific Meeting, 24-29 October 2008, USA.

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Product Promise

Promise
Molecular Weight (MW)426.26
Molecular FormulaC17H14BrN3O2S
CAS No.1151516-14-1
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: ≥ 30mg/mLr
Water: N/Ar
Ethanol: N/A
SMILES CodeO=C(O[Na])CSC1=NN=C(Br)N1C2=C3C=CC=CC3=C(C4CC4)C=C2
SynonymsRDEA594 sodium; RDEA 594; RDEA-594; Zurampic
ProtocolIn VitroLesinurad (RDEA594) is a potential uric acid lowering agent througn inhibition of uric acid reuptake, and exhibits favorable p450 profiles, inhibits CYP2C9 and CYP2C8 with IC50 of 14.4 μM and 16.2 μM, respectively. IC50s of Lesinurad are all above 100 µM for CYP1A2, CYP2C19,and CYP2D6
In VivoLesinurad (RDEA594) shows better pharmacokinetics than its pro-drug RDEA806. The 100 mg dose of Lesinurad exhibits a phamacological effect in the range of that produced by 300 mg to 800 mg single doses of RDEA806
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.3460 mL11.7299 mL23.4599 mL46.9197 mL
5mM0.4692 mL2.3460 mL4.6920 mL9.3839 mL
10mM0.2346 mL1.1730 mL2.3460 mL4.6920 mL
20mM0.1173 mL0.5865 mL1.1730 mL2.3460 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.