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Size | Price | Stock |
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250mg | $450 | Check With Us |
500mg | $750 | Check With Us |
1g | $1125 | Check With Us |
Cat #: V3306 CAS #: 1151516-14-1 Purity ≥ 98%
Description: Lesinurad sodium (formerly known as RDEA594; RDEA-594; trade name Zurampic), the sodium salt of lesinurad, is a selective inhibitor of URAT1 (urate transporter 1) and OAT (organic anion transporter) approved in 2015 for treating high blood uric acid levels associated with gout.
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Molecular Weight (MW) | 426.26 |
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Molecular Formula | C17H14BrN3O2S |
CAS No. | 1151516-14-1 |
Storage | -20℃ for 3 years in powder formr |
-80℃ for 2 years in solvent | |
Solubility In Vitro | DMSO: ≥ 30mg/mLr |
Water: N/Ar | |
Ethanol: N/A | |
SMILES Code | O=C(O[Na])CSC1=NN=C(Br)N1C2=C3C=CC=CC3=C(C4CC4)C=C2 |
Synonyms | RDEA594 sodium; RDEA 594; RDEA-594; Zurampic |
Protocol | In Vitro | Lesinurad (RDEA594) is a potential uric acid lowering agent througn inhibition of uric acid reuptake, and exhibits favorable p450 profiles, inhibits CYP2C9 and CYP2C8 with IC50 of 14.4 μM and 16.2 μM, respectively. IC50s of Lesinurad are all above 100 µM for CYP1A2, CYP2C19,and CYP2D6 |
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In Vivo | Lesinurad (RDEA594) shows better pharmacokinetics than its pro-drug RDEA806. The 100 mg dose of Lesinurad exhibits a phamacological effect in the range of that produced by 300 mg to 800 mg single doses of RDEA806 |
Solvent volume to be added | Mass (the weight of a compound) | |||
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Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
1mM | 2.3460 mL | 11.7299 mL | 23.4599 mL | 46.9197 mL |
5mM | 0.4692 mL | 2.3460 mL | 4.6920 mL | 9.3839 mL |
10mM | 0.2346 mL | 1.1730 mL | 2.3460 mL | 4.6920 mL |
20mM | 0.1173 mL | 0.5865 mL | 1.1730 mL | 2.3460 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.