Deutetrabenazine (SD-809)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1550	Check With Us
500mg	$2480	Check With Us
1g	$3720	Check With Us

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Cat #: V3922 CAS #: 1392826-25-3 Purity ≥ 98%

Description: Deutetrabenazine (formerly known as SD-809; GTPL8707; tetrabenazine-d6; trade name Austedo), the hexa-deuterated form of tetrabenazine, is an orally bioactive, small-molecule vesicular monoamine transporter 2 (VMAT2) inhibitor which has been approved by FDA in 2017 for the treatment of chorea associated with Huntington's disease and tardive dyskinesia.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	323.47
Molecular Formula	C19H21D6NO3
CAS No.	1392826-25-3
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10 mMr
	Water: N/Ar
	Ethanol: N/A
SMILES Code	O=C1[C@H](CC(C)C)CN2CCC3=CC(OC([2H])([2H])[2H])=C(OC([2H])([2H])[2H])C=C3[C@@]2([H])C1
Synonyms	Deutetrabenazine; Tetrabenazine-d6; SD809; GTPL-8707; SD-809; GTPL8707; SD 809; GTPL 8707; trade name Austedo

Protocol	In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, primarily as tracers for quantification during drug development. Deuteration is a cause for concern because it may affect the pharmacokinetics and metabolic profile of drugs

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.0915 mL	15.4574 mL	30.9148 mL	61.8295 mL
5mM	0.6183 mL	3.0915 mL	6.1830 mL	12.3659 mL
10mM	0.3091 mL	1.5457 mL	3.0915 mL	6.1830 mL
20mM	0.1546 mL	0.7729 mL	1.5457 mL	3.0915 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.