This product is for research use only, not for human use. We do not sell to patients.
| Size | Price | Stock |
|---|---|---|
| 100mg | $2750 | Check With Us |
| 250mg | $3980 | Check With Us |
| 500mg | $5970 | Check With Us |
: Cat #: V3598 CAS #: 1253186-49-0 Purity ≥ 98%
Description: GSK-5498A is a novel, potent and selective small molecule blocker of Calcium-Release Activated Calcium (CRAC) channel with IC50 of 1 uM; It inhibits mediator release from mast cells, and pro-inflammatory cytokine release from T-cells in a variety of species.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 399.29 |
|---|---|
| Molecular Formula | C₁₈H₁₁F₆N₃O |
| CAS No. | 1253186-49-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent |
| Protocol | In Vitro | GSK-5498A (1 and 10 μM) inhibits calcium influx through CRAC channels in human embryonic kidney cells[1]. GSK-5498A (1 nM-10 μM) inhibits the thapsigargin-evoked fluorescence signal (pIC50: 6.3) in Jurkat cells, measured using the calcium sensitive dye: Fluo4-AM |
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| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5044 mL | 12.5222 mL | 25.0445 mL | 50.0889 mL |
| 5mM | 0.5009 mL | 2.5044 mL | 5.0089 mL | 10.0178 mL |
| 10mM | 0.2504 mL | 1.2522 mL | 2.5044 mL | 5.0089 mL |
| 20mM | 0.1252 mL | 0.6261 mL | 1.2522 mL | 2.5044 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.