Ercalcitriol (RO-17-6218)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$3750	To Be Confirmed
200mg	$5625	To Be Confirmed
500mg	$9495	To Be Confirmed

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Cat #: V20676 CAS #: 60133-18-8 Purity ≥ 99%

Description: Ercalcitriol (RO-17-6218 or 1,25-dihydroxyvitamin D2, 1α,25-Dihydroxy Vitamin D2) is the active metabolite and circulating form of vitamin D2 formed by 25-hydroxylase in the liver and 25-hydroxyvitamin D-hydroxylase in the kidney.

References: Mawer EB, Berry JL, Cundall JP, Still PE, White A.A sensitive radioimmunoassay using a monoclonal antibody that is equipotent for ercalcitriol and calcitriol (1,25-dihydroxy vitamin D2 and D3).Clin Chim Acta. 1990 Oct 15;190(3):199-209.

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Molecular Weight (MW)	428.65
Molecular Formula	C28H44O3
CAS No.	60133-18-8
SMILES Code	O[C@H]1C[C@H](O)C(/C(C1)=CC=C2[C@]3([H])CC[C@H]([C@H](C)/C=C/C(C)C(C)(O)C)[C@@]3(C)CCC2)=C
Synonyms	RO-17-6218; RO 17-6218; RO17-6218; Ercalcitriol; 1,25-Dihydroxyvitamin D2; 1,25-Dihydroxycalciferol; 1,25-Dihydroxyergocalciferol;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3329 mL	11.6645 mL	23.3291 mL	46.6581 mL
5mM	0.4666 mL	2.3329 mL	4.6658 mL	9.3316 mL
10mM	0.2333 mL	1.1665 mL	2.3329 mL	4.6658 mL
20mM	0.1166 mL	0.5832 mL	1.1665 mL	2.3329 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.