Calcipotriol Monohydrate

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1400	Check With Us
500mg	$1950	Check With Us
1g	$2925	Check With Us

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Cat #: V17430 CAS #: 147657-22-5 Purity ≥ 98%

Description: Calcipotriol hydrate (Daivonex; Dovonex; MC-903; PRI-2201; Psorcutan; Sorilux), the hydrated form of calcipotriol, is a synthetic calcitriol/Vitamin D3 (VD3) analog and a potent agonist of the VD3 receptor (VDR) used in the treatment of psoriasis and marketed under the trade name Dovonex.

References: Al-Jaderi Z, et al. Effects of vitamin D3, calcipotriol and FTY720 on the expression of surface molecules and cytolytic activities of human natural killer cells and dendritic cells. Toxins (Basel). 2013 Oct 28;5(11):1932-47.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	430.62
Molecular Formula	C27H42O4
CAS No.	147657-22-5
SMILES Code	C[C@@H]([C@H]1CC[C@H]2/C(CCC[C@]12C)=C/C=C3C[C@H](C[C@@H](C/3=C)O)O)/C=C/[C@H](C4CC4)O.O
Synonyms	Calcipotriol Monohydrate; Calcipotriene;

Protocol	In Vitro	When NHEK cells are not stimulated with IL-17A or IL-22, Calcipotriol slightly enhances (0.2 nM) IL-8 mRNA expression or has no effect (2-20 nM). The addition of IL-17A and IL-22 markedly increased the mRNA expression of IL-8, confirming our previous study. This enhanced IL-8 mRNA expression is suppressed by Calcipotriol at 2, 20 and 40 nM in a dose dependent manner.
Protocol	In Vivo	One out of the 32 animals in each of the groups has died, except for the Diclofenac plus DFMO plus Calcipotriol group, where all animals survived. Survival is equally distributed between the groups. The weight gain is significantly smaller in the groups treated with Diclofenac plus Calcipotriol (p=0.018) and Diclofenac plus DFMO plus Calcipotriol (p=0.002) compare with placebo (linear regression model).

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3222 mL	11.6112 mL	23.2223 mL	46.4447 mL
5mM	0.4644 mL	2.3222 mL	4.6445 mL	9.2889 mL
10mM	0.2322 mL	1.1611 mL	2.3222 mL	4.6445 mL
20mM	0.1161 mL	0.5806 mL	1.1611 mL	2.3222 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.