L-Thyroxine sodium salt pentahydrate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 10g | $250 | To Be Confirmed |
| 25g | $450 | To Be Confirmed |
| 50g | $675 | To Be Confirmed |
: Cat #: V29928 CAS #: 6106-07-6 Purity ≥ 99%
Description: L-Thyroxine sodium salt pentahydrate is an endogenous iodine-bearing thyroid hormone produced from thyroglobulin in the thyroid follicular cells.
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- Related Biological Data
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| Molecular Weight (MW) | 888.93 |
|---|---|
| Molecular Formula | C15H20I4NNaO9 |
| CAS No. | 6106-07-6 |
| Synonyms | Sodium levothyroxine pentahydrate |
| Protocol | In Vivo | Deiodinases (DIOs), which catalyse the conversion of thyroxine (pro-hormone) to the active thyroid hormone, are associated with thyroid stimulating hormone (TSH) levels. DIO1 and DIO2 catalyze activation of thyroid hormone secretion in contrast to DIO3 playing role inactivation of the secretion. Activities of DIO1 and DIO2 play pivotal role in the negative feedback regulation of pituitary TSH secretion. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.1249 mL | 5.6247 mL | 11.2495 mL | 22.4990 mL |
| 5mM | 0.2250 mL | 1.1249 mL | 2.2499 mL | 4.4998 mL |
| 10mM | 0.1125 mL | 0.5625 mL | 1.1249 mL | 2.2499 mL |
| 20mM | 0.0562 mL | 0.2812 mL | 0.5625 mL | 1.1249 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.