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GDC-0927 Racemate

This product is for research use only, not for human use. We do not sell to patients.

GDC-0927 Racemate
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1800To Be Confirmed
250mg$2980To Be Confirmed
500mg$4470To Be Confirmed
email: [email protected]        [email protected]

Cat #: V3804 CAS #: 1443983-36-5 Purity ≥ 98%

Description: GDC-0927 Racemate, the racemic mixture of GDC-0927, is used in the research of ER-related diseases.

References: Mehmet Kahraman, et al. Estrogen receptor modulator and uses thereof. WO2014205138A1.

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Molecular Weight (MW)461.53
Molecular FormulaC28H28FNO4
CAS No.1443983-36-5
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 10 mMr
Water: N/Ar
Ethanol: N/A
SynonymsSRN-927; SRN 927; SRN927; GDC-0927; GDC 0927; GDC0927
ProtocolIn VitroGDC-0927 Racemate (Example 1) is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC50 of 0.2 nM, and is used in the research of ER-related diseases. GDC-0927 Racemate reduces the viability of MCF7 cells with an IC50 of 0.21 nM.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.1667 mL10.8335 mL21.6671 mL43.3341 mL
5mM0.4333 mL2.1667 mL4.3334 mL8.6668 mL
10mM0.2167 mL1.0834 mL2.1667 mL4.3334 mL
20mM0.1083 mL0.5417 mL1.0834 mL2.1667 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.