AR-C155858
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $1450 | To Be Confirmed |
| 100mg | $2150 | To Be Confirmed |
| 200mg | $3225 | To Be Confirmed |
: Cat #: V11349 CAS #: 496791-37-8 Purity ≥ 98%
Description: AR-C155858 is a novel, selective and potent inhibitor of monocarboxylate transporters MCT1 and MCT2 with Kis of 2.3 nM and 10 nM, respectively.
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| Molecular Weight (MW) | 461.53 |
|---|---|
| Molecular Formula | C21H27N5O5S |
| CAS No. | 496791-37-8 |
| SMILES Code | O=C1N(CC(C)C)C2=C(C(C(N3OC[C@@H](O)C3)=O)=C(CC4=C(C)NN=C4C)S2)C(N1C)=O |
| Protocol | In Vitro | AR-C155858 inhibits MCT2, and the 70% inhibition seen at 10 nM is followed by a gradually increasing inhibition which can only be explained by a Ki value of significantly less than 10 nM. AR-C155858 inhibits MCT1 expressed in Xenopus oocytes in a time- and concentration-dependent manner |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1667 mL | 10.8335 mL | 21.6671 mL | 43.3341 mL |
| 5mM | 0.4333 mL | 2.1667 mL | 4.3334 mL | 8.6668 mL |
| 10mM | 0.2167 mL | 1.0834 mL | 2.1667 mL | 4.3334 mL |
| 20mM | 0.1083 mL | 0.5417 mL | 1.0834 mL | 2.1667 mL |
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.