Ipragliflozin
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $599 | Check With Us |
| 500mg | $869 | Check With Us |
| 1g | $1300 | Check With Us |
: Cat #: V3129 CAS #: 761423-87-4 Purity ≥ 98%
Description: Ipragliflozin (also known as ASP1941) is a novel, highly potent and selective inhibitor of the sodium-glucose cotransporter 2 (SGLT2) with IC50 value of 7.4 nM for hSGLT2.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 404.45 |
|---|---|
| Molecular Formula | C21H21FOS |
| CAS No. | 761423-87-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 80 mg/mL (197.8 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 80 mg/mL (197.8 mM) | |
| SMILES Code | O[C@H]1[C@H](C2=CC=C(F)C(CC3=CC4=CC=CC=C4S3)=C2)O[C@H](CO)[C@@H](O)[C@@H]1O |
| Synonyms | ASP-1941; ASP1941; ASP 1941; Ipragliflozin |
| Protocol | In Vitro | Ipragliflozin-induced weakening of cell proliferation was completely canceled after using siRNA knockdown SGLT2 expression, indicating that |
|---|---|---|
| In Vivo | Ipragliflozin has an antihyperglycemic effect. Ipragliflozin (0.1-1 mg/kg) dose-dependently suppresses an increase in blood glucose levels. In STZ-induced rats with type 1 diabetes, the effect was significant at doses of 0.3 and 1 mg/kg, compared with KK-Ay In mice with type 2 diabetes, the effect was significant at all tested doses | |
| Animal model | Single Administration | |
| Dosages | 0.1-1 mg/kg | |
| Administration | Single oral administration in the fed condition. Blood glucose levels were then measured for 8 h under fasting conditions |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4725 mL | 12.3625 mL | 24.7249 mL | 49.4499 mL |
| 5mM | 0.4945 mL | 2.4725 mL | 4.9450 mL | 9.8900 mL |
| 10mM | 0.2472 mL | 1.2362 mL | 2.4725 mL | 4.9450 mL |
| 20mM | 0.1236 mL | 0.6181 mL | 1.2362 mL | 2.4725 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.