ERTUGLIFLOZIN
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $439 | Check With Us |
| 1g | $669 | Check With Us |
| 5g | $1805 | Check With Us |
: Cat #: V3906 CAS #: 1210344-57-2 Purity ≥ 98%
Description: Ertugliflozin (formerly known as PF04971729; PF-04971729; trade name: Steglatro) is an orally bioactive and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2) with hypoglycemic and antidiabetic activity.
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- Related Biological Data
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| Molecular Weight (MW) | 436.89 |
|---|---|
| Molecular Formula | C22H25ClO7 |
| CAS No. | 1210344-57-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 45 mg/mLr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | O[C@@H]1[C@](O2)(CO)CO[C@]2(C3=CC=C(Cl)C(CC4=CC=C(C=C4)OCC)=C3)[C@H](O)[C@H]1O |
| Synonyms | PF-04971729; PF 04971729; PF04971729; PF-04971729-00 |
| Protocol | In Vitro | Ertugliflozin (PF-04971729) exhibits >2-fold selectivity for SGLT1 inhibition (relative to SGLT2000) in vitro |
|---|---|---|
| In Vivo | Ertugliflozin (PF-04971729) exhibits concentration-dependent glycosuria after oral administration in rats |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2889 mL | 11.4445 mL | 22.8891 mL | 45.7781 mL |
| 5mM | 0.4578 mL | 2.2889 mL | 4.5778 mL | 9.1556 mL |
| 10mM | 0.2289 mL | 1.1445 mL | 2.2889 mL | 4.5778 mL |
| 20mM | 0.1144 mL | 0.5722 mL | 1.1445 mL | 2.2889 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.