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ERTUGLIFLOZIN PIDOLATE

This product is for research use only, not for human use. We do not sell to patients.

ERTUGLIFLOZIN PIDOLATE
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$320Check With Us
500mg$520Check With Us
1g$780Check With Us
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Cat #: V3907 CAS #: 1210344-83-4 Purity ≥ 98%

Description: Ertugliflozin pidolate (formerly known as also known as PF-04971729; trade name: Steglatro), the pidolate salt of ertugliflozin, is a potent, orally bioavailable and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2)approved in 2017 by FDA for treating type 2 diabetes mellitus.

References: Kalgutkar AS, et al. Preclinical species and human disposition of PF-04971729, a selective inhibitor of the sodium-dependent glucose cotransporter 2 and clinical candidate for the treatment of type 2 diabetes mellitus. Drug Metab Dispos. 2011 Sep;39(9):1609-19.

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Molecular Weight (MW)566.0
Molecular FormulaC27H32ClNO10
CAS No.1210344-83-4
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: ≥ 50 mg/mLr
Water: N/Ar
Ethanol: N/A
SMILES CodeCCOc1ccc(Cc2c(Cl)ccc([C@]34OC[C@](O3)([C@H]([C@@H]([C@H]4O)O)O)CO)c2)cc1.OC([C@@H] 5CCC(N5)=O)=O
SynonymsPF-04971729 pidolate; PF 04971729; PF04971729; PF-04971729-00; Ertugliflozin pidolate; Ertugliflozin L-pyroglutamic acid
ProtocolIn VitroErtugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) demonstrates >2000-fold selectivity for SGLT2 inhibition (relative to SGLT1) in vitro
In VivoErtugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) reveals a concentration-dependent glucosuria after oral administration to rats
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.7668 mL8.8339 mL17.6678 mL35.3357 mL
5mM0.3534 mL1.7668 mL3.5336 mL7.0671 mL
10mM0.1767 mL0.8834 mL1.7668 mL3.5336 mL
20mM0.0883 mL0.4417 mL0.8834 mL1.7668 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Volume(start)
V1
 
=
 
Concentration(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.