Licogliflozin (LIK-066)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
50mg	$1250	To Be Confirmed
100mg	$1875	To Be Confirmed
200mg	$2825	To Be Confirmed

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Cat #: V24111 CAS #: 1291094-73-9 Purity ≥ 99%

Description: Licogliflozin (LIK066) is a novel, potent and orally bioavailable dual inhibitor of sodium-glucose transporter-1 (SGLT1) and sodium-glucose transporter-2 (SGLT2), with an in vivo inhibitory concentration (IC50) of 22.0 nM against human SGLT1 and 0.5 nM against human SGLT2.

References: Monica A. Konerman, et al. Overview of Clinical Treatment Trials for NASH.Curr Hepatol Rep. 2017 Dec;16(4): 366-373.

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Molecular Weight (MW)	416.46
Molecular Formula	C23H28O7
CAS No.	1291094-73-9
SMILES Code	O[C@H]1[C@H](C2=CC=C(CC)C(CC3=CC=C4OCCOC4=C3)=C2)O[C@H](CO)[C@@H](O)[C@@H]1O
Synonyms	LIK066; LIK-066; LIK 066; licogliflozin

Protocol	In Vitro	Licogliflozin (LIK066) is a non-anti-fibrotic treatment agent for non-alcoholic steatohepatitis (NASH).

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4012 mL	12.0060 mL	24.0119 mL	48.0238 mL
5mM	0.4802 mL	2.4012 mL	4.8024 mL	9.6048 mL
10mM	0.2401 mL	1.2006 mL	2.4012 mL	4.8024 mL
20mM	0.1201 mL	0.6003 mL	1.2006 mL	2.4012 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.