NBQX Disodium

This product is for research use only, not for human use. We do not sell to patients.

NBQX Disodium
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
50mg$650Check With Us
100mg$1050Check With Us
200mg$1575Check With Us

Cat #: V16605 CAS #: 479347-86-9 Purity ≥ 98%

Description: NBQX (also known as FG9202) is a novel, potent selective and competitive antagonist of aminomethylphosphonic acid receptor (AMPAR) with IC50 of 0.7 ± 0.1 μM.

References: Fukushima K, et al. Characterization of Human Hippocampal Neural Stem/Progenitor Cells and Their Application to Physiologically Relevant Assays for Multiple Ionotropic Glutamate Receptors. J Biomol Screen. 2014 Sep; 19(8):1174-84.

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Molecular Weight (MW)380.24
Molecular FormulaC12H7N4NaO6S
CAS No.479347-86-9
SMILES CodeO=S(C1=C2C(C3=C([N-]C(C([N-]3)=O)=O)C=C2[N+]([O-])=O)=CC=C1)(N)=O.[Na+].[Na+] 
SynonymsNBQX disodium; FG9202; FG-9202; FG 9202
ProtocolIn VitroNBQX disodium (FG9202 disodium) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex
In VivoNBQX disodium is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.6299 mL13.1496 mL26.2992 mL52.5984 mL
5mM0.5260 mL2.6299 mL5.2598 mL10.5197 mL
10mM0.2630 mL1.3150 mL2.6299 mL5.2598 mL
20mM0.1315 mL0.6575 mL1.3150 mL2.6299 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.