LY-3130481 | CAS 1610802-47-5

LY-3130481

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$2350	Check With Us
250mg	$3350	Check With Us
500mg	$5025	Check With Us

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Cat #: V4851 CAS #: 1610802-47-5 Purity ≥ 98%

Description: LY3130481 (also known as CERC-611) is a novel and potent α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist t that is dependent upon transmembrane AMPA receptor regulatory protein (TARP) γ-8, it selective inhibits AMPA/TARP γ-8 with an IC50 of 65 nM.

References: Gardinier KM,et al. Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8. J Med Chem. 2016 May 26;59(10):4753-68.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	382.44
Molecular Formula	C19H18N4O3S
CAS No.	1610802-47-5
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.6148 mL	13.0739 mL	26.1479 mL	52.2958 mL
5mM	0.5230 mL	2.6148 mL	5.2296 mL	10.4592 mL
10mM	0.2615 mL	1.3074 mL	2.6148 mL	5.2296 mL
20mM	0.1307 mL	0.6537 mL	1.3074 mL	2.6148 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.