PhTx-74 diHCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $750 | To Be Confirmed |
| 100mg | $1250 | To Be Confirmed |
| 200mg | $1875 | To Be Confirmed |
: Cat #: V27543 CAS #: 1227301-51-0 Purity ≥ 99%
Description: PhTx-74 HCl (Philanthotoxin 74; PhTx 74; PhTx74), the dihydrochloride salt of PhTx-74, is an analogue of philanthotoxin-4,3,3 which is a naturally-occurring wasp venom toxin.
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| Molecular Weight (MW) | 507.54 |
|---|---|
| Molecular Formula | C24H44Cl2N4O3 |
| CAS No. | 1227301-51-0 |
| Synonyms | PhTx 74; PhTx74; Philanthotoxin 74; Philanthotoxin74 |
| Protocol | In Vitro | Philanthotoxin 74 in the micromolar concentration range displays selective inhibition between the two major subtypes of GluA2R-containing AMPARs, GluA1/A2R and GluA2R/A3, when these are coexpressed with γ-2 in oocytes. Philanthotoxin 74 is reported to fully inhibit GluA1/A2R receptors when applied at a concentration of 500 μM while producing 10% inhibition at GluA2R/A3 receptors. Philanthotoxin 74, when tested at concentrations of 100 and 500 μM, displays pronounced channel block (more than 80%) of GluA1/A2R but minimal block (less than 10%) of GluA2R/A3. Oocytes expressing GluA2R alone that homomeric GluA2R is virtually inert to philanthotoxin 74 in the 0.1-300 μM concentration range, displaying less than 5% inhibition at the maximum tested concentration of 300 μM. Philanthotoxin 74 inhibits these receptors nonselectively, with IC50 values of about 30 μM, in both the presence and absence of γ-2 |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9703 mL | 9.8514 mL | 19.7029 mL | 39.4058 mL |
| 5mM | 0.3941 mL | 1.9703 mL | 3.9406 mL | 7.8812 mL |
| 10mM | 0.1970 mL | 0.9851 mL | 1.9703 mL | 3.9406 mL |
| 20mM | 0.0985 mL | 0.4926 mL | 0.9851 mL | 1.9703 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
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mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.