GNE-8324 | CAS 1698901-76-6

GNE-8324

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
25mg	$1200	In Stock
50mg	$1800	In Stock
100mg	$2700	In Stock

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Cat #: V4907 CAS #: 1698901-76-6 Purity ≥ 98%

Description: GNE-8324 (GNE8324) is a novel, potent and selective PAM (Positive Allosteric Modulators) of NMDA receptor. NMDA Receptors (NMDARs) play key roles in synaptic physiology and NMDAR hypofunction has been implicated in various neurological conditions.

References: Lulu Yao, et al. Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity. Nat Commun. 2018 Oct 1;9(1):4000.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	343.42
Molecular Formula	C18H18FN3OS
CAS No.	1698901-76-6
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent

Protocol	In Vitro	A reciprocal allosteric interaction between the GNE-8324 and glutamate binding sites at GluN2A NMDARs such that binding of glutamate enhances binding of GNE-8324 and vice versa. GNE-8324 selectively potentiates GluN2A subunit-containing NMDARs. As a consequence, GNE-8324 potentiation is highly dependent on glutamate site occupancy with enhanced GNE-8324 binding to glutamate-bound NMDARs compared to glutamate-free NMDARs

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.9119 mL	14.5594 mL	29.1189 mL	58.2377 mL
5mM	0.5824 mL	2.9119 mL	5.8238 mL	11.6475 mL
10mM	0.2912 mL	1.4559 mL	2.9119 mL	5.8238 mL
20mM	0.1456 mL	0.7280 mL	1.4559 mL	2.9119 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.