Zatebradine (UL-FS-49; UL-FS-49CL)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $450 | Check With Us |
| 100mg | $750 | Check With Us |
| 200mg | $1125 | Check With Us |
: Cat #: V29094 CAS #: 85175-67-3 Purity ≥ 99%
Description: Zatebradine (UL-FS-49; UL-FS-49CL) is a novel and potent bradycardic agent which inhibits hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 values 1.96 µM.
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| Molecular Weight (MW) | 456.57 |
|---|---|
| Molecular Formula | C₂₆H₃₆N₂O₅ |
| CAS No. | 85175-67-3 |
| Synonyms | UL-FS-49 free base; UL-FS-49CL free base; UL-FS49; UL FS49 |
| Protocol | In Vivo | Zatebradine (0-20 mg/kg; intraperitoneal injection; for 30 minutes; male C57/Bl6-mice) reduces the heart rate dose-dependently from 600 to 200 bpm with ED50 value of 1.8 mg/kg and induces increasing arrhythmia. |
|---|---|---|
| Animal model | Male C57/Bl6-mice | |
| Dosages | 0 mg/kg, 0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg | |
| Administration | Intraperitoneal injection; for 30 minutes |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1902 mL | 10.9512 mL | 21.9024 mL | 43.8049 mL |
| 5mM | 0.4380 mL | 2.1902 mL | 4.3805 mL | 8.7610 mL |
| 10mM | 0.2190 mL | 1.0951 mL | 2.1902 mL | 4.3805 mL |
| 20mM | 0.1095 mL | 0.5476 mL | 1.0951 mL | 2.1902 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.