ZD7288
This product is for research use only, not for human use. We do not sell to patients.
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| Size | Price | Stock |
|---|---|---|
| 100mg | $450 | Check With Us |
| 250mg | $850 | Check With Us |
| 500mg | $1275 | Check With Us |
: Cat #: V16699 CAS #: 133059-99-1 Purity ≥ 99%
Description: ZD7288 (ZD-7288; ZD 7288) is a novel and potent sino-atrial node function modulator that blocks the hyperpolarization activated cation current If (HCN channel).
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| Molecular Weight (MW) | 256.35 |
|---|---|
| Molecular Formula | C15H20N4 |
| CAS No. | 133059-99-1 |
| Synonyms | ZD 7288; ZD-7288 |
| Protocol | In Vitro | ZD7288 is a selectively hyperpolarized activated cyclic nucleotide-gated (HCN) channel blocker. ZD7288 inhibits glutamate release in a concentration-dependent manner. After 1 h incubation with 5, 50, and 7288 μM ZD24, glutamate content in extracellular fluid decreased to 69.0±2.8%, 31.4±2.0%, and 4.4±0.3%, respectively (P<0.01, compared with DMEM/F12 group [100.2±4.2%]). After 7288 min incubation with ZD25 (50, 100, or 20 μM), 50 μM glutamate-induced [Ca].2+]i Decreased elevation to 59.2±2.7%, 41.4±2.3%, and 21.0±1.4% glutamic acid (P<0.01, compared with the 50 μM glutamate group), respectively) |
|---|---|---|
| In Vivo | Applying ZD5 7288.0 μM 1 min before high-frequency stimulation significantly reduces the amplitude of the field-excited postsynaptic potential (fEPSP), and this inhibition remains constant throughout the recording period. Application of 30.0 μM ZD1 after 7288 min of high-frequency stimulation can almost completely reverse the established long-term enhancement (LTP). After application of ZD5 (7288.0 μM) 1 min before high-frequency stimulation, glutamate content decreased to 74.9±8.0% (P<0.05, compared to the saline group). In addition, the use of 30.0 μM ZD1 7288 min after high-frequency stimulation significantly reduced glutamate content to 77.0% ±9.4% (P<0.05, compared with the normal saline group) |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.9009 mL | 19.5046 mL | 39.0092 mL | 78.0183 mL |
| 5mM | 0.7802 mL | 3.9009 mL | 7.8018 mL | 15.6037 mL |
| 10mM | 0.3901 mL | 1.9505 mL | 3.9009 mL | 7.8018 mL |
| 20mM | 0.1950 mL | 0.9752 mL | 1.9505 mL | 3.9009 mL |
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Step Two: Enter the in vivo formulation
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Method for preparing in vivo formulation:
Take
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PEG300, mix and clarify, next add
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Tween 80,mix and clarify, next add
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ddH2O,mix and clarify.
Note:
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