Zatebradine HCl (UL-FS49; UL-FS49CL)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $750 | Check With Us |
| 250mg | $1350 | Check With Us |
| 500mg | $2025 | Check With Us |
: Cat #: V26699 CAS #: 91940-87-3 Purity ≥ 99%
Description: Zatebradine HCl (UL-FS 49; UL-FS 49CL), the hydrochloride salt of Zatebradine, is a novel and potent bradycardic agent which inhibits hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 values 1.96 µM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 493.04 |
|---|---|
| Molecular Formula | C26H37ClN2O5 |
| CAS No. | 91940-87-3 |
| SMILES Code | O=C1CC2=CC(OC)=C(OC)C=C2CCN1CCCN(CCC3=CC=C(OC)C(OC)=C3)C.[H]Cl |
| Protocol | In Vivo | Zatebradine (0-20 mg/kg; intraperitoneal injection; for 30 minutes; male C57/Bl6-mice) reduces the heart rate dose-dependently from 600 to 200 bpm with ED50 value of 1.8 mg/kg and induces increasing arrhythmia |
|---|---|---|
| Animal model | Male C57/Bl6-mice | |
| Dosages | 0 mg/kg, 0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg | |
| Administration | Intraperitoneal injection; for 30 minutes |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0282 mL | 10.1412 mL | 20.2823 mL | 40.5647 mL |
| 5mM | 0.4056 mL | 2.0282 mL | 4.0565 mL | 8.1129 mL |
| 10mM | 0.2028 mL | 1.0141 mL | 2.0282 mL | 4.0565 mL |
| 20mM | 0.1014 mL | 0.5071 mL | 1.0141 mL | 2.0282 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.