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YHO-13177

This product is for research use only, not for human use. We do not sell to patients.

YHO-13177
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1178Check With Us
500mg$1885Check With Us
1g$2825Check With Us
email: [email protected]        [email protected]

Cat #: V28371 CAS #: 912287-56-0 Purity ≥ 99%

Description: YHO-13177 is a potent and specific inhibitor of breast cancer resistance protein (BCRP/ABCG2).

References: Yamazaki R, et al. Novel acrylonitrile derivatives, YHO-13177 and YHO-13351, reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo. Mol Cancer Ther. 2011 Jul;10(7):1252-63.

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Molecular Weight (MW)370.46
Molecular FormulaC20H22N2O3S
CAS No.912287-56-0
SynonymsYHO-13177; YHO 13177; YHO13177
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.6993 mL13.4967 mL26.9935 mL53.9869 mL
5mM0.5399 mL2.6993 mL5.3987 mL10.7974 mL
10mM0.2699 mL1.3497 mL2.6993 mL5.3987 mL
20mM0.1350 mL0.6748 mL1.3497 mL2.6993 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.