LY2365109

This product is for research use only, not for human use. We do not sell to patients.

LY2365109
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$750To Be Confirmed
250mg$1300To Be Confirmed
500mg$1950To Be Confirmed

Cat #: V24677 CAS #: 1779796-27-8 Purity ≥ 99%

Description: LY2365109 (LY-2365109) is a novel and potent glycine transporter 1 (GlyT1) inhibitor (IC50 = 15.8 nM) with the potential to be used as an antiictogenic drug.

References: Perry KW et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology. 2008 Oct;55(5):743-54.

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Molecular Weight (MW)421.92
Molecular FormulaC22H28ClNO5
CAS No.1779796-27-8
SynonymsLY-2365109; LY 2365109
ProtocolIn VivoLY2365109 hydrochloride (0.3-30 mg/kg; p.o.) produces dose-dependent elevations in CSF levels of glycine
Animal modelMale Sprague-Dawley rats (250-300 g)
Dosages0.3 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg, 30 mg/kg
AdministrationOral administration
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.3701 mL11.8506 mL23.7012 mL47.4024 mL
5mM0.4740 mL2.3701 mL4.7402 mL9.4805 mL
10mM0.2370 mL1.1851 mL2.3701 mL4.7402 mL
20mM0.1185 mL0.5925 mL1.1851 mL2.3701 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.