Iinerixibat (GSK2330672)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$1500	Check With Us
250mg	$2300	Check With Us
500mg	$3450	Check With Us

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Cat #: V3633 CAS #: 1345982-69-5 Purity ≥ 98%

Description: Linerixibat (formerly known as GSK2330672; GSK-2330672) is a novel, highly potent and nonabsorbable inhibitor of ASBT (apical sodium-dependent bile acid transporter) under development for cholestatic pruritus in primary biliary cholangitis.

References: Wu Y, et al. Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes. J Med Chem. 2013 Jun 27;56(12):5094-114.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	546.68
Molecular Formula	C28H38N2O7S
CAS No.	1345982-69-5
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent

Protocol	In Vitro	The zwitterionic, non-hygroscopic crystalline salt form of Linerixibat (Compound 56) shows good water solubility (>7 mg/mL), excellent thermal stability, and no reactive or human-specific metabolites at pH 4.7
	In Vivo	Linerixibat (GSK2330672； 0.05-10 mg/kg； oral gavage; twice a day; Lasts 14 days; Male ZDF rats) treatment reduces glucose in animal models of type 2 diabetes
	Animal model	Male Zucker Diabetic Fatty (ZDF) rat
	Dosages	0.05 mg/kg, 0.1 mg/kg, 0.5 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg
	Administration	Oral gavage; twice daily; for 14 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.8292 mL	9.1461 mL	18.2922 mL	36.5845 mL
5mM	0.3658 mL	1.8292 mL	3.6584 mL	7.3169 mL
10mM	0.1829 mL	0.9146 mL	1.8292 mL	3.6584 mL
20mM	0.0915 mL	0.4573 mL	0.9146 mL	1.8292 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.