Odevixibat | CAS 501692-44-0

Odevixibat

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
50mg	$700	To Be Confirmed
100mg	$1200	To Be Confirmed
200mg	$1800	To Be Confirmed

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Cat #: V9853 CAS #: 501692-44-0 Purity ≥ 98%

Description: Odevixibat (formerly known as A-4250; AZD-8294; A-4250; AR-H 064974; Bylvay) is a novel, potent and orally bioavailable inhibitor of ileal bile acid transporter (IBAT) with the potential to be used for the treatment of primary biliary cirrhosis.

References: Baghdasaryan A, et al. Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis.J Hepatol. 2016 Mar;64(3):674-81.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	740.93
Molecular Formula	C37H48N4O8S2
CAS No.	501692-44-0
Synonyms	AZD8294; A4250; AR-H064974; AZD-8294; A-4250; AR-H-064974

Protocol	In Vivo	Odevixibat (A4250)(0.01% (w/w) in chow diet; 4 weeks) improves sclerosing cholangitis and significantly reduces serum alanine aminotransferase, alkaline phosphatase and BAs levels, hepatic expression of pro-inflammatory and pro-fibrogenic genes and bile duct proliferation in Mdr2-/- mice
	Animal model	Eight week old Mdr2-/- (Abcb4-/-) mice (model of cholestatic liver injury and sclerosing cholangitis)
	Dosages	0.01% (w/w) in chow diet

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.3497 mL	6.7483 mL	13.4966 mL	26.9931 mL
5mM	0.2699 mL	1.3497 mL	2.6993 mL	5.3986 mL
10mM	0.1350 mL	0.6748 mL	1.3497 mL	2.6993 mL
20mM	0.0675 mL	0.3374 mL	0.6748 mL	1.3497 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.