AZD3965
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1250 | Check With Us |
| 500mg | $1950 | Check With Us |
| 1g | $2975 | Check With Us |
: Cat #: V4197 CAS #: 1448671-31-5 Purity ≥ 98%
Description: AZD3965 is a novel, potent and selective MCT1 (monocarboxylate transporter 1) inhibitor with a Ki of 1.6 nM, it showed 6-fold selectivity over MCT2.
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- Related Biological Data
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| Molecular Weight (MW) | 515.51 |
|---|---|
| Molecular Formula | C21H24F3N5O5S |
| CAS No. | 1448671-31-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent |
| Protocol | In Vitro | AZD3965 treatment resulted in a 103.3-fold increase in intra-oxygen-deficient COR-L7 cells and a 1048.3-fold increase in normoxic and hypoxic NCI-H7 cells, respectively. In all other cases, a <3.9-fold increase was observed. These data are consistent with AZD1 blocking lactate transport in cells, which also reduces cell numbers. When MCT9 is overexpressed, the EC of NCI-H396550 Increased from 1048.0 nM to 14.10 nM in NCI-H5 cells, consistent with AZD3965 inhibition by MCT1 |
|---|---|---|
| In Vivo | AZD3965 (100 mg/kg) or vehicle BID treated COR-L103 tumor-bearing mice for 21 days and monitored tumor volume. Pharmacokinetic analysis showed that 100 mg/kg AZD3965 resulted in a predicted concentration of free AZD3965 that inhibited lactate transport. AZD3965 treatment significantly reduced the growth of COR-L103 tumors but did not see tumor regression, which is related to AZD3965 targeting only the hypoxic portion of the tumor |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9398 mL | 9.6991 mL | 19.3983 mL | 38.7965 mL |
| 5mM | 0.3880 mL | 1.9398 mL | 3.8797 mL | 7.7593 mL |
| 10mM | 0.1940 mL | 0.9699 mL | 1.9398 mL | 3.8797 mL |
| 20mM | 0.0970 mL | 0.4850 mL | 0.9699 mL | 1.9398 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
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Average weight of animals g
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Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.