JPH203 free base

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
50mg	$900	To Be Confirmed
100mg	$1550	To Be Confirmed
200mg	$2325	To Be Confirmed

: [email protected] [email protected]

Cat #: V5459 CAS #: 1037592-40-7 Purity ≥ 99%

Description: JPH203 (KYT-0353; JPH-203) is a novel and potent anti-cancer drug targeting L-type amino acid transporter 1 (LAT1), which plays a primary role in the uptake of essential amino acids in tumor cells.

References: Yun DW, et al. J Pharmacol Sci. 2014, 124(2):208-17.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	472.322
Molecular Formula	C23H19Cl2N3O
CAS No.	1037592-40-7
Synonyms	KYT 0353; JPH203; KYT0353; nanvuranlat; JPH 203; KYT-0353

Protocol	In Vitro	In YD-38 and NHOKs cells, JPH203 completely or slightly inhibits L-Leucine uptake with IC50s of 0.79 μM and greater than 100 μM, respectively. JPH203 inhibits the growth of HT-29 cells with an IC50 of 4.1 μM; The IC50 value (0.06 μM) that inhibits L-Leucine uptake does not inhibit the growth of HT-29 cells

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.1172 mL	10.5860 mL	21.1720 mL	42.3440 mL
5mM	0.4234 mL	2.1172 mL	4.2344 mL	8.4688 mL
10mM	0.2117 mL	1.0586 mL	2.1172 mL	4.2344 mL
20mM	0.1059 mL	0.5293 mL	1.0586 mL	2.1172 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.