PPQ-102 | CAS 931706-15-9

PPQ-102

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$1450	Check With Us
500mg	$2080	Check With Us
1g	$3020	Check With Us

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Cat #: V2875 CAS #: 931706-15-9 Purity ≥ 99%

Description: PPQ-102 (also known as CFTR Inhibitor) is a potent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator) discovered from screening of approximately 110000 small synthetic and natural compounds for inhibition of halide influx in CFTR-expressing epithelial cells.

References: Tradtrantip L, et al. Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem. 2009 Oct 22; 52(20):6447-55.

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Stock Solution Preparation
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Molecular Weight (MW)	438.48
Molecular Formula	C26H22N4O3
CAS No.	931706-15-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: ≥ 52 mg/mLr
	Water: <1 mg/mLr
	Ethanol:
SMILES Code	O=C1N(C)C(C(C(N1C)=O)=C2C3=CC=CC=C3)=C4N2C5=C(C=CC=C5)NC4C6=CC=C(C)O6
Synonyms	PPQ 102; PPQ102; PPQ-102.

Protocol	In Vitro	PPQ-102 (0,0.5,5 μM, 4 days) prevents and reverses renal cyst dilation in a PKD embryonic kidney organ culture model

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2806 mL	11.4030 mL	22.8061 mL	45.6121 mL
5mM	0.4561 mL	2.2806 mL	4.5612 mL	9.1224 mL
10mM	0.2281 mL	1.1403 mL	2.2806 mL	4.5612 mL
20mM	0.1140 mL	0.5702 mL	1.1403 mL	2.2806 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.