Avatrombopag maleate

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$450	To Be Confirmed
500mg	$750	To Be Confirmed
1g	$1125	To Be Confirmed

: [email protected] [email protected]

Cat #: V3892 CAS #: 677007-74-8 Purity ≥ 98%

Description: Avatrombopag maleate (formerly AKR501, YM477, AS1670542; E5501; AKR-501, YM-477, AS-1670542; E-5501; Doptelet), the maleate salt of Avatrombopag, is an orally bioactive thrombopoietin (TPO) receptor agonist approved in 2008 to treat patients with chronic idiopathic thrombocytopenic purpura.

References: Fukushima-Shintani M, et al. AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist. Eur J Haematol. 2009;82(4):247-254.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	649.65
Molecular Formula	C29H34Cl2N6O3S2
CAS No.	677007-74-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: ≥ 30 mg/mLr
	Water: < 1 mg/mLr
	Ethanol: < 1 mg/mL
SMILES Code	O=C(C1CCN(C2=NC=C(C(NC3=NC(C4=CC(Cl)=CS4)=C(N5CCN(C6CCCCC6)CC5)S3)=O)C=C2Cl)CC1)O
Synonyms	YM477; YM-477; YM 477; AKR501; AKR 501; AKR-501; E5501; E 5501; E-5501; AS 1670542; AS1670542; AS-1670542

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.5393 mL	7.6965 mL	15.3929 mL	30.7858 mL
5mM	0.3079 mL	1.5393 mL	3.0786 mL	6.1572 mL
10mM	0.1539 mL	0.7696 mL	1.5393 mL	3.0786 mL
20mM	0.0770 mL	0.3848 mL	0.7696 mL	1.5393 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.