Oleandrin
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1350 | Check With Us |
| 250mg | $2160 | Check With Us |
| 500mg | $3240 | Check With Us |
: Cat #: V26869 CAS #: 465-16-7 Purity ≥ 99%
Description: Oleandrin is a novel and potent cardiac glycoside.
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| Molecular Weight (MW) | 576.72 |
|---|---|
| Molecular Formula | C32H48O9 |
| CAS No. | 465-16-7 |
| SMILES Code | CC(O[C@H]1C[C@]2(O)C3CC[C@]4([H])C[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)CC[C@]4(C)[C@@]3([H])CC[C@]2(C)C1C6=CC(OC6)=O)=O |
| Synonyms | PBI-05204; PBI 05204; PBI05204 |
| Protocol | In Vivo | The effect of Oleandrin is investigated on glioma growth in vivo. To this aim, SCID or C57BL/6 mice are transplanted, respectively, with human U87MG (5×104), U251, GBM19 (5×105), or murine (syngeneic) GL261 (7.5×104) cells into the right striatum and, after 10 d, treated daily with intraperitoneal Oleandrin for an additional 7 d. Oleandrin significantly reduces tumor sizes in human and murine glioma cell models in vivo in a dose-dependent way. High concentrations of Oleandrin (3 mg/kg) are fatal in both models, as expected from the known lethal dose for rodents. Doses of Oleandrin below the lethal dose (0.3 mg/kg) significantly increase the survival time from 32.6±1.4 d to 53.8±9.6 d in mice injected with U87MG cells (n=5-11; p<0.01, log-rank test) and from 23.37±1.2 d to 34.38±3.3 d (n=5-11; p<0.01, log rank test) in mice injected with GL261 cells |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7339 mL | 8.6697 mL | 17.3394 mL | 34.6789 mL |
| 5mM | 0.3468 mL | 1.7339 mL | 3.4679 mL | 6.9358 mL |
| 10mM | 0.1734 mL | 0.8670 mL | 1.7339 mL | 3.4679 mL |
| 20mM | 0.0867 mL | 0.4335 mL | 0.8670 mL | 1.7339 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.