Cyclosporin D
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1050 | To Be Confirmed |
| 200mg | $1575 | To Be Confirmed |
| 500mg | $2655 | To Be Confirmed |
: Cat #: V40415 CAS #: 63775-96-2 Purity ≥ 99%
Description: Cyclosporin D is a nonpolar cyclic oligopeptide and a novel metabolite of Cyclosporin A, which is an immunosuppressant agent that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells.
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- Related Biological Data
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| Molecular Weight (MW) | 1216.64 |
|---|---|
| Molecular Formula | C63H113N11O12 |
| CAS No. | 63775-96-2 |
| Synonyms | Cyclosporin D |
| Protocol | In Vitro | Cyclosporine D inhibits Ca2+/calmodulin dependent EF-2 phosphorylation in vitro. |
|---|---|---|
| In Vivo | Cyclosporine D is a potent inhibitor in vivo of phorbol ester TPA-induced biological effects in mouse skin. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 0.8219 mL | 4.1097 mL | 8.2194 mL | 16.4387 mL |
| 5mM | 0.1644 mL | 0.8219 mL | 1.6439 mL | 3.2877 mL |
| 10mM | 0.0822 mL | 0.4110 mL | 0.8219 mL | 1.6439 mL |
| 20mM | 0.0411 mL | 0.2055 mL | 0.4110 mL | 0.8219 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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V1
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.