MRT67307
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1150 | Check With Us |
| 500mg | $1850 | Check With Us |
| 1g | $2775 | Check With Us |
: Cat #: V2613 CAS #: 1190378-57-4 Purity ≥ 98%
Description: MRT67307 (MRT-67307; MRT 67307) is a novel and potent inhibitor for multiple kinases such as TBK1, IKKε , MARK1-4 and NUAK1 with potential antineoplastic activity.
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| Molecular Weight (MW) | 464.6 (free-base) |
|---|---|
| Molecular Formula | C26H36N6O2 |
| CAS No. | 1190378-57-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 92 mg/mLr |
| Water: 92 mg/mLr | |
| Ethanol: N/A | |
| Synonyms | MRT67307; MRT-67307; MRT 67307; MRT67307 HCl |
| Protocol | In Vitro | MRT67307 (1 nM-10 μM) prevents the production of IFNβ in macrophages. MRT67307 (2 μM) prevents the phosphorylation of IRF3 in bone-marrow-derived macrophages (BMDMs). MRT67307 (2 μM) dose not suppresse the activation of JNK or p38 MAPK by poly(I:C). MRT67307 inhibits IKKϵ and TBK1 with IC50 values of 160 and 19 nM when assayed at 0.1 mM ATP in vitro, but did not inhibit IKKα or IKKβ even at 10 μM. |
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These protocols are for reference only. InvivoChem does not
independently validate these methods.
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
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Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.