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Evixapodlin

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Evixapodlin
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$3000Check With Us
200mg$4500Check With Us
500mg$7590Check With Us
email: [email protected]        [email protected]

Cat #: V3348 CAS #: 2374856-75-2 Purity ≥ 99%

Description: Evixapodlin(also known as PD-1/PD-L1-IN 7) is a programmed cell death ligand 1 (PD-L1) inhibitor.

References: Evangelos Aktoudianakis, et al. Pd-1/pd-l1 inhibitors. WO2019160882A1.

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Molecular Weight (MW)691.61
Molecular FormulaC34H36Cl2N8O4
CAS No.2374856-75-2
SMILES CodeO=C1CC[C@@]([H])(CNCC2=NC=C(C3=CC=CC(C4=C(Cl)C(C5=NC(OC)=C(CNC[C@@]6([H])NC(CC6)=O)N=C5)=CC=C4)=C3Cl)N=C2OC)N1
SynonymsEvixapodlin
ProtocolIn VitroEvixapodlin (compound 139) enhances IFN-γ and Granzyme B Production in chronic hepatitis B (CHB) CD8+ T Cells and CD4+ T Cells. Evixapodlin also enhances the frequency of GrB+ cells among HBV-specific CD8+ and CD4+ T cells. The ability of Evixapodlin to enhance the antiviral functions of HBV-specific CD8+ and CD4+ T cells in vitro is comparable to those of Durvalumab.
In VivoEvixapodlin (Compound 139; 10-50 mg/kg; intraperitoneal injection, daily, for 6 days) treatment shows >90% PD-L1 target occupancy (TO) on the tumor cells. Evixapodlin significantly inhibits tumor growth in a human PD-L1 expressing MC38 mouse colorectal tumor model.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.4459 mL7.2295 mL14.4590 mL28.9180 mL
5mM0.2892 mL1.4459 mL2.8918 mL5.7836 mL
10mM0.1446 mL0.7230 mL1.4459 mL2.8918 mL
20mM0.0723 mL0.3615 mL0.7230 mL1.4459 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.