Fraxinellone
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
Size | Price | Stock |
---|---|---|
100mg | $550 | To Be Confirmed |
200mg | $825 | To Be Confirmed |
500mg | $1390 | To Be Confirmed |
Cat #: V21365 CAS #: 28808-62-0 Purity ≥ 99%
Description: Fraxinellone is a naturally occurring anti-inflammatory agent isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus.
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Molecular Weight (MW) | 232.28 |
---|---|
Molecular Formula | C14H16O3 |
CAS No. | 28808-62-0 |
SMILES Code | C1(C=2[C@@]([C@@H](O1)c1cocc1)(CCCC2C)C)=O |
Synonyms | Fraxinellone |
Protocol | In Vitro | Fraxinellone (0-100 μM;12 hours) decreases the percent of PD-L1 positive cells from 20.4% to 11.4% in A549 cells. |
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In Vivo | Fraxinellone (oral gavage; 30 and 100 mg/kg; every three days; 30 days) significantly suppresses tumor growth, reduces HIF-1α, pTyr705 STAT3, PD-L1 and VEGF staining compared with the control group in female athymic BALB/c nude mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
Solvent volume to be added | Mass (the weight of a compound) | |||
---|---|---|---|---|
Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
1mM | 4.3051 mL | 21.5257 mL | 43.0515 mL | 86.1030 mL |
5mM | 0.8610 mL | 4.3051 mL | 8.6103 mL | 17.2206 mL |
10mM | 0.4305 mL | 2.1526 mL | 4.3051 mL | 8.6103 mL |
20mM | 0.2153 mL | 1.0763 mL | 2.1526 mL | 4.3051 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.