Fraxinellone

This product is for research use only, not for human use. We do not sell to patients.

Fraxinellone
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$550To Be Confirmed
200mg$825To Be Confirmed
500mg$1390To Be Confirmed

Cat #: V21365 CAS #: 28808-62-0 Purity ≥ 99%

Description: Fraxinellone is a naturally occurring anti-inflammatory agent isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus.

References: Xing Y, et al. Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3. Pharmacol Res. 2018 Sep;135:166-180.

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Molecular Weight (MW)232.28
Molecular FormulaC14H16O3
CAS No.28808-62-0
SMILES CodeC1(C=2[C@@]([C@@H](O1)c1cocc1)(CCCC2C)C)=O
SynonymsFraxinellone
ProtocolIn VitroFraxinellone (0-100 μM;12 hours) decreases the percent of PD-L1 positive cells from 20.4% to 11.4% in A549 cells.
In VivoFraxinellone (oral gavage; 30 and 100 mg/kg; every three days; 30 days) significantly suppresses tumor growth, reduces HIF-1α, pTyr705 STAT3, PD-L1 and VEGF staining compared with the control group in female athymic BALB/c nude mice.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM4.3051 mL21.5257 mL43.0515 mL86.1030 mL
5mM0.8610 mL4.3051 mL8.6103 mL17.2206 mL
10mM0.4305 mL2.1526 mL4.3051 mL8.6103 mL
20mM0.2153 mL1.0763 mL2.1526 mL4.3051 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.