Diltiazem HCl (Tiazac, RG 83606)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 10g | $245 | Check With Us |
| 20g | $367 | Check With Us |
| 50g | $650 | Check With Us |
: Cat #: V0518 CAS #: 33286-22-5 Purity ≥ 98%
Description: Diltiazem HCl (Tiazac, RG-83606 HCl) is a benzothiazepine derivative and a calcium-channel blocker (CCB) with vasodilating activity.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 450.98 |
|---|---|
| Molecular Formula | C22H26N2O4S.HCl |
| CAS No. | 33286-22-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 90 mg/mL (199.6 mM)r |
| Water: 90 mg/mL (199.6 mM)r | |
| Ethanol: 4 mg/mL (8.9 mM) | |
| Solubility In Vivo | Chemical Name: (2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate hydrochloride InChi Key: HDRXZJPWHTXQRI-BHDTVMLSSA-N InChi Code: InChI=1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1 SMILES Code: O=C1[C@H](OC(C)=O)[C@H](C2=CC=C(OC)C=C2)SC3=CC=CC=C3N1CCN(C)C.[H]Cl |
| Synonyms | RG83606 Hydrochloride; RG 83606 HCl; RG-83606 HCl; RG 83606; RG-83606; CRD-401; CRD401; RG83606 HCl; CRD 401; Tiazac; Dilzene |
| Protocol | In Vitro | Benzothiazepine Ca2+ antagonist diltiazem hydrochloride interacts with transmembrane segments IIIS6 and IVS6 in the α1 subunit of L-type Ca2+ channels |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2174 mL | 11.0870 mL | 22.1739 mL | 44.3479 mL |
| 5mM | 0.4435 mL | 2.2174 mL | 4.4348 mL | 8.8696 mL |
| 10mM | 0.2217 mL | 1.1087 mL | 2.2174 mL | 4.4348 mL |
| 20mM | 0.1109 mL | 0.5543 mL | 1.1087 mL | 2.2174 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.