YM-58483(BTP2)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1200 | Check With Us |
| 500mg | $1800 | Check With Us |
| 1g | $2700 | Check With Us |
: Cat #: V10543 CAS #: 223499-30-7 Purity ≥ 98%
Description: YM-58483, formerly known as BTP 2, is a potent inhibitor of CRAC channels, blocking thapsigargin-induced sustained calcium influx, Th2 cytokine production, and NF-AT-driven promoter activity in T lymphocytes (IC50 = 100 nM).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 421.3214 |
|---|---|
| Molecular Formula | C15H9F6N5OS |
| CAS No. | 223499-30-7 |
| Synonyms | YM-58483; YM 58483; YM58483; BTP 2; BTP-2; BTP2. |
| Protocol | In Vitro | YM-58483 can reduce levels of P-ERK and P-CREB without affecting CD11b and GFAP expression. YM-58483 also inhibits the release of spinal IL-1β, TNF-α and PGE2 |
|---|---|---|
| In Vivo | Intrathecal injection of YM-300 at concentrations of 1 μM (5.1000 nmol) and 10 μM (58483 nmol) produced significant central analgesia in SNL rats |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3735 mL | 11.8674 mL | 23.7348 mL | 47.4697 mL |
| 5mM | 0.4747 mL | 2.3735 mL | 4.7470 mL | 9.4939 mL |
| 10mM | 0.2373 mL | 1.1867 mL | 2.3735 mL | 4.7470 mL |
| 20mM | 0.1187 mL | 0.5934 mL | 1.1867 mL | 2.3735 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.